American Cruise Lines

American Cruise Lines operates a fleet of small, U.S.-flagged ships built specifically for domestic river and coastal itineraries, including the Mississippi, Columbia and Snake Rivers, and New England and the Pacific Northwest. Every voyage sails entirely within the United States, with an all-American crew and no international ports of call.
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Cruises with American Cruise Lines

American Glory
American Cruise Lines

15-night East Coast Inland Passage Cruise

American Glory
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 15 nights
Destination: Small Ships, Florida, Charleston, SC
Baltimore, MD/Amelia Island, FL
American Song
American Cruise Lines

8-night Columbia and Snake Rivers Cruise

American Song
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Pacific Northwest
Clarkston/Portland
American Splendor
American Cruise Lines

8-night Lower Mississippi River Cruise

American Splendor
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Mississippi River Cruise
New Orleans/Memphis
American Symphony
American Cruise Lines

8-night Lower Mississippi River Cruise

American Symphony
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Mississippi River Cruise
Memphis/New Orleans
American Encore
American Cruise Lines

8-night Columbia and Snake Rivers Cruise

American Encore
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Pacific Northwest
Portland, OR/Clarkston, WA
American Maverick
American Cruise Lines

8-night Florida Gulf Coast & Keys Cruise

American Maverick
Contact Advisor for pricing
Departure: Nov 3, 2026
Length: 8 nights
Destination: Small Ships, Florida, Florida Keys & Key West
Tampa/St. Petersburg, FL
American Melody
American Cruise Lines

8-night Lower Mississippi River Cruise

American Melody
Contact Advisor for pricing
Departure: Nov 6, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Mississippi River Cruise
Memphis/New Orleans
American Harmony
American Cruise Lines

8-night Columbia and Snake Rivers Cruise

American Harmony
Contact Advisor for pricing
Departure: Nov 6, 2026
Length: 8 nights
Destination: River Cruises, Small Ships, Pacific Northwest
Portland, OR/Clarkston, WA

View all 2899 cruises with American Cruise Lines